BMC Complement Altern Med. 2017 Mar 4;17(1):137.
N-butanol extracts of Morinda citrifolia suppress advanced glycation end products (AGE)-induced inflammatory reactions in endothelial cells through its anti-oxidative properties
Ishibashi Y, Matsui T, Isami F, Abe Y, Sakaguchi T, Higashimoto Y, Yamagishi SI.
Noni extracts significantly inhibited AGE-induced reactive oxygen species generation, AGE receptor (RAGE), and intercellular adhesion molecule-1 and plasminogen activator inhibitor-1 gene expressions in human umbilical vein endothelial cells (HUVECs). This study demonstrated that the noni extract suppresses AGE-induced inflammatory reactions through antioxidant action that involves the blocking of RAGE binding. (original abstract at https://www.ncbi.nlm.nih.gov/pubmed/28259164).