Cancer Letters, 73:161-166, 1993
Induction of Normal Phenotypes in ras-transformed Cells by Damnacanthal from Morinda citrifolia
Hiramatsu, T., Imoto, M., Koyano, T., Umezawa, K.
An anthraquinone, damnacanthal, was isolated from the chloroform extract of the root of Morinda citrifolia. Damnacanthal induced normal morphology and cytoskeletal structure modification in ras-transformed cancer cells. Thus damnacanthal is a new inhibitor of ras function (which is responsible for these cells becoming cancerous).