Proceedings of the Western Pharmacology Society, 37:145-146, 1994
Anticancer Activity of Morinda citrifolia (Noni) on Intraperitoneally Implanted Lewis Lung Carcinoma in Syngeneic Mice
Hirazumi, A., Furusawa, E., Chou, S.C., Hokama, Y.
Morinda citrifolia (noni) juice was shown to have antitumor activity on Lewis Lung carcinoma in mice. The ethanol precipitate (noni-ppt) was not directly toxic to cancer cells. Instead, it acts indirectly by enhancing the host immune system involving macrophages or lymphocytes. Noni-ppt had a beneficial effect when combined with sub-optimal doses of chemotherapeutic agents. This suggests a possibility of clinical application of noni-ppt in cancer treatment.