Otology & Neurotology 2016 Sep;37(8):e303-8.
Oxidative Damage and Inflammation Biomarkers: Strategy in Hearing Disorders.
Haase GM, Prasad KN.
To provide the otology investigator a useful panel of biomarkers that can be used as reasonable secondary endpoints in hearing and balance research, this report highlights some of the most clinically relevant and well-studied biomarkers in each category of tissue damage. The authors highlight the use of these biomarkers in clinical trials of micronutrient supplementation. A 6-month open-label trial increased immune competency and decreased oxidative stress as measured by plasma and urinary malondialdehyde. During a 3-month, placebo-controlled trial with military subjects, a 20% increase urinary F2-isoprostane levels was eliminated with micronutrient supplementation. After 3 months of intensive training in military subjects, micronutrient ingestion reduced the percentage of people with high levels of oxidative damaged DNA. Expression of an inflammatory enzyme, iNOS, was increased in rodents following blast wave injury. However, pretreatment with antioxidant micronutrients reduced this inflammatory response.
(original abstract available at https://www.ncbi.nlm.nih.gov/pubmed/27518139).