Journal of Cosmetics, Dermatological Sciences and Applications. 2012, 2, 74-78.
Noni seed oil topical safety, efficacy, and potential mechanisms of action.
Palu AK, West BJ, Jensen CJ.
Noni seed oil did not cause any skin reactions in a repeat insult patch test with 49 adult volunteers. Noni seed oil was non-comedogenic in a four-week clinical trial involving 23 adolescent volunteers. The oil also exhibited in-vitro anti-inflammatory activity in COX-2 and 5-LOX enzyme inhibition assays. The results demonstrate that noni seed oil is safe for topical use and is non-comedogenic. (original abstract available at http://www.scirp.org/journal/PaperInformation.aspx?paperID=20117).