American Journal of Otolaryngology 2011 Jan-Feb;32(1):55-61.
Antioxidant micronutrient impact on hearing disorders: concept, rationale, and evidence.
Haase GM, Prasad KN, Cole WC, Baggett-Strehlau JM, Wyatt SE.
This review outlines the rationale for utilizing antioxidant micronutrients for a range hearing disorders. A comprehensive micronutrient approach is useful in against oxidative damage and inflammation as well provides neuroprotection. Clinical trials of antioxidant micronutrients have also shown the following:
- Reduction of oxidative damage measured in plasma and urine over six months, with a concomitant increase in immune competency as measured by the lymphocyte transformation assay,
- Protection against oxidative damage during 12 weeks of intense military training,
- Nerve VIII function improvement after concussive head injury in military personnel,
- Tinnitus improvement in patients after 90-days evaluation.
In vivo studies have also demonstrated the ability of micronutrients to protect against inflammation after total body blast exposure and to provide neuroprotection against chemically-induced Parkinson’s disease.
(original abstract available at https://www.ncbi.nlm.nih.gov/pubmed/20015808).