American Journal of Otolaryngology 2011 Jan-Feb;32(1):55-61.
Antioxidant micronutrient impact on hearing disorders: concept, rationale, and evidence.
Haase GM, Prasad KN, Cole WC, Baggett-Strehlau JM, Wyatt SE.

This review outlines the rationale for utilizing antioxidant micronutrients for a range hearing disorders. A comprehensive micronutrient approach is useful in against oxidative damage and inflammation as well provides neuroprotection. Clinical trials of antioxidant micronutrients have also shown the following:

  1. Reduction of oxidative damage measured in plasma and urine over six months, with a concomitant increase in immune competency as measured by the lymphocyte transformation assay,
  2. Protection against oxidative damage during 12 weeks of intense military training,
  3. Nerve VIII function improvement after concussive head injury in military personnel,
  4. Tinnitus improvement in patients after 90-days evaluation. 

In vivo studies have also demonstrated the ability of micronutrients to protect against inflammation after total body blast exposure and to provide neuroprotection against chemically-induced Parkinson’s disease.
(original abstract available at https://www.ncbi.nlm.nih.gov/pubmed/20015808).